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:: Volume 1, Issue 1 (Autumn-Winter 2015) ::
3 2015, 1(1): 6-12 Back to browse issues page
Polyphenols and cancer: A review
Soheila Moein
Biochemistry Department Hormozgan University of Medical Sciences, Banad Abbas, Iran
Abstract:   (1555 Views)

Introduction: Atherosclerosis, hypertension, ischemic diseases, Alzheimer’s disease, Parkinson disease, cancer and inflammation emerge from imbalance between antioxidant and oxidants. Cancer is a most important public health problem in both developed and developing countries. Natural antioxidants such as polyphenols are being used for prevention and treatment cancer. Polyphenols include phenolic acids, flavonoids, stilbenes, lignanas and tannins. This article explains different activities of polyphenols in prevention of cancer and discusses the multiple approach which these phytochemicals merit proper position in therapeutic of cancer. In cancer, these compounds induce apoptosis, reduction the number of tumors, inhibition angiogenesis, modulation of multidrug resistance and antiproliferat- ive activity. In tumor cells, signal transduction cause proliferation in cancer cells. Polyphenols inhibit signal transduction such as protein kinase C, tyrosine kinase and serine/ threonine kinase. Diverse anticancer mechanisms of some polyphenols like resveratol, epigallo catechin gallate, curcumin and genestin are discussed in this article.

Keywords: Polyphenols, Flavonoids, Anticancer properties, Antiproliferation, Signaling inhibition
Full-Text [PDF 471 kb]   (1406 Downloads)    
Type of Study: Research | Subject: General
Received: 2015/06/6 | Accepted: 2015/06/6 | Published: 2015/06/6
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Moein S. Polyphenols and cancer: A review. 3. 2015; 1 (1) :6-12
URL: http://mmj.hums.ac.ir/article-1-23-en.html

Volume 1, Issue 1 (Autumn-Winter 2015) Back to browse issues page
مجله پزشکی مولکولی Molecular Medicine Journal
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