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:: Volume 1, Number 1 (Autumn-Winter 2015) ::
3 2015, 1(1): 13-19 Back to browse issues page
3-D cell modeling and investigating its movement on non-rigid substrates
Mohammad Hadi Mahmoudi Nejad , Wyra Parwaie
Abstract:   (1158 Views)

Introduction: Attachment of blood and tissue cells to the extracellular matrix (ECM) is done with the help of specific joints, which are made between cells’ receptors and matrixes’ ligands. This interaction is vital for many biological activities such as cell migration, cancer development, and wound healing. The purpose of this study is to model a 3-dimensional cell by ABAQUS commercial software package and investigate effects of factors, including mechanical properties of focal adhesion, substrate stiffness and cell active stress on cell motility over a smooth non-rigid substrate.

Methods: In our model, the cell is assumed to be a continuum and continuum mechanics equations are used for the cell, also due to symmetry in the geometry of the problem, symmetric approach has been applied in order to conserve timep.

Results: Simulation results of this modeling demonstrate that mechanical properties of focal adhesion between cell and substrate and also substrate stiffness have considerable effect on cell motility.

Conclusion: In fact, increase in substrate stiffness and also increase in focal adhesion strength cause an increase in magnitude of cell-substrate traction stress and on the other hand, increase in these two parameters causes cell motility velocity to continue its decreasing trend. Furthermore, magnitude of traction stress and cell movement speed highly depends on the active stress in the cell which perceptible increase can be observed in these two values when active stress increases. These results agree with experimental data reported by other authors.

Keywords: Cell motility, 3-D Finite element model, Non-rigid substrate, Traction, Focal adhesion
Full-Text [PDF 572 kb]   (701 Downloads)    
Type of Study: Research | Subject: General
Received: 2015/06/6 | Accepted: 2015/06/6 | Published: 2015/06/6
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Mahmoudi Nejad M H, Parwaie W. 3-D cell modeling and investigating its movement on non-rigid substrates. 3. 2015; 1 (1) :13-19
URL: http://mmj.hums.ac.ir/article-1-24-en.html
Volume 1, Number 1 (Autumn-Winter 2015) Back to browse issues page
مجله پزشکی مولکولی Molecular Medicine Journal
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