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:: Volume 1, Issue 1 (Autumn-Winter 2015) ::
3 2015, 1(1): 20-22 Back to browse issues page
Prevalence of HLA-B27 in the group of patients referred to Danesh clinical laboratory
Najmeh Ahangari , Alireza Pourreza , Elaheh Ahangari , Majid Jouybari
Abstract:   (1339 Views)

Background: HLA B27 is a sub class of Human leukocyte antigen (HLA) class I molecule. It was known as the first genetic risk factor associating with ankylosing spondylitis (AS). Allele Frequency of HLA-B27 alleles is different across populations. The present study is aimed to investigate the prevalence of HLA-B27 in patients referred to Danesh clinical laboratory during 2014 to 2015. Methods and material: Among 178 patient referred to our lab, 171 data were valid. 5ml blood samples were obtained in heparinized tubes for HLA typing test. Direct typing of the HLA-B27 allele was performed by the standard micro lymphocytotoxity test (MLCT method). Result: A total of 171 patients have been typed for HLA-B27. The prevalence of HLA-B27 positive was found as 16.4%. Conclusion: A national level of HLA B27 prevalence approximation is required for public health management particularly because of recent improvements in diagnostic testing for the disorder

Keywords: HLA B27, Prevalence, Epidemiology, diagnosis
Full-Text [PDF 294 kb]   (798 Downloads)    
Type of Study: Research | Subject: Special
Received: 2015/09/6 | Accepted: 2015/09/6 | Published: 2015/09/6
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Ahangari N, Pourreza A, Ahangari E, Jouybari M. Prevalence of HLA-B27 in the group of patients referred to Danesh clinical laboratory. 3. 2015; 1 (1) :20-22
URL: http://mmj.hums.ac.ir/article-1-30-en.html

Volume 1, Issue 1 (Autumn-Winter 2015) Back to browse issues page
مجله پزشکی مولکولی Molecular Medicine Journal
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